Reaction Details |
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Target | Apoptosis regulator Bcl-2 |
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Ligand | BDBM21410 |
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Substrate/Competitor | Fluorescein-labeled BAX peptide |
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Meas. Tech. | Fluorescence Polarization Assay and FL5.12 Cellular Assay |
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Ki | 56±n/a nM |
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EC50 | 700±n/a nM |
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Citation | Bruncko, M; Oost, TK; Belli, BA; Ding, H; Joseph, MK; Kunzer, A; Martineau, D; McClellan, WJ; Mitten, M; Ng, SC; Nimmer, PM; Oltersdorf, T; Park, CM; Petros, AM; Shoemaker, AR; Song, X; Wang, X; Wendt, MD; Zhang, H; Fesik, SW; Rosenberg, SH; Elmore, SW Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. J Med Chem50:641-62 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Apoptosis regulator Bcl-2 |
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Name: | Apoptosis regulator Bcl-2 |
Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
Type: | Homodimer or heterodimer |
Mol. Mass.: | 26269.11 |
Organism: | Homo sapiens (Human) |
Description: | P10415 |
Residue: | 239 |
Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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BDBM21410 |
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Fluorescein-labeled BAX peptide |
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Name: | Fluorescein-labeled BAX peptide |
Synonyms: | n/a |
Type: | fluorescein-labeled probe |
Mol. Mass.: | 2800.15 |
Organism: | n/a |
Description: | n/a |
Residue: | 25 |
Sequence: | FITC-QDASTKKLSECLKRIGDELDS
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