Reaction Details |
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Target | Focal adhesion kinase 1 [410-689] |
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Ligand | BDBM418851 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Activity Assay |
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IC50 | 0.616±n/a nM |
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Citation | Luzzio, MJ; Freeman-Cook, KD; Bhattacharya, SK; Hayward, MM; Hulford, CA; Autry, CL; Zhao, X; Xiao, J; Nelson, KL Sulfonyl amide derivatives for the treatment of abnormal cell growth US Patent US10450297 Publication Date 10/22/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Focal adhesion kinase 1 [410-689] |
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Name: | Focal adhesion kinase 1 [410-689] |
Synonyms: | FAK | FAK1 | FAK1_HUMAN | Focal adhesion kinase 1 (FAK) (aa 410-689) | PTK2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 32163.33 |
Organism: | Homo sapiens (Human) |
Description: | aa 410-689 |
Residue: | 280 |
Sequence: | PSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFL
QEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQ
LSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM
APESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPP
TLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEE
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BDBM418851 |
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n/a |
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Name | BDBM418851 |
Synonyms: | N-[3-({[2-({4-[(1R)-1- aminoethyl]phenyl}amino)-5- (trifluoromethyl)pyrimidin-4- yl]amino}methyl)pyrazin-2-yl]-N- methylmethane-sulfonamide (351), hydrochloride salt | US10450297, Example 351 | US10450297, Example 355 |
Type | Small organic molecule |
Emp. Form. | C20H23F3N8O2S |
Mol. Mass. | 496.509 |
SMILES | C[C@H](N)c1ccc(Nc2ncc(c(NCc3nccnc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1 |r| |
Structure |
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