| Reaction Details |
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 | Report a problem with these data |
| Target | Focal adhesion kinase 1 [410-689] |
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| Ligand | BDBM418860 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Activity Assay |
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| IC50 | <0.595±n/a nM |
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| Citation |  Luzzio, MJ; Freeman-Cook, KD; Bhattacharya, SK; Hayward, MM; Hulford, CA; Autry, CL; Zhao, X; Xiao, J; Nelson, KL Sulfonyl amide derivatives for the treatment of abnormal cell growth US Patent US10450297 Publication Date 10/22/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Focal adhesion kinase 1 [410-689] |
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| Name: | Focal adhesion kinase 1 [410-689] |
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| Synonyms: | FAK | FAK1 | FAK1_HUMAN | Focal adhesion kinase 1 (FAK) (aa 410-689) | PTK2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 32163.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 410-689 |
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| Residue: | 280 |
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| Sequence: | PSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFL
QEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQ
LSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM
APESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPP
TLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEE
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| BDBM418860 |
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| n/a |
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| Name | BDBM418860 |
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| Synonyms: | 2-chloro-4-({4-[({3- [methyl(methylsulfonyl)amino]pyrazin-2- yl}methyl)amino]-5- (trifluoromethyl)pyrimidin-2- yl}amino)benzamide (360) | US10450297, Example 360 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18ClF3N8O3S |
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| Mol. Mass. | 530.911 |
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| SMILES | CN(c1nccnc1CNc1nc(Nc2ccc(C(N)=O)c(Cl)c2)ncc1C(F)(F)F)S(C)(=O)=O |
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| Structure | 
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