Reaction Details |
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Target | Sodium-dependent dopamine transporter |
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Ligand | BDBM22400 |
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Substrate/Competitor | BDBM22166 |
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Meas. Tech. | Ligand Binding Assay |
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Ki | 28±n/a nM |
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EC50 | 41±n/a nM |
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Citation | Gong, PK; Blough, BE; Brieaddy, LE; Huang, X; Kuhar, MJ; Navarro, HA; Carroll, FI Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-[5-(substituted phenyl)thiazol-2-yl]tropanes. J Med Chem50:3686-95 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Sodium-dependent dopamine transporter |
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Name: | Sodium-dependent dopamine transporter |
Synonyms: | DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 68497.11 |
Organism: | Homo sapiens (Human) |
Description: | Q01959 |
Residue: | 620 |
Sequence: | MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
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BDBM22400 |
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BDBM22166 |
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Name | BDBM22400 |
Synonyms: | 5-(4-chlorophenyl)-2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octan-2-yl]-1,3-thiazole | WIN 35,065-2 Analogue, 4c |
Type | Small organic molecule |
Emp. Form. | C23H22Cl2N2S |
Mol. Mass. | 429.405 |
SMILES | CN1[C@H]2CC[C@@H]1[C@H]([C@H](C2)c1ccc(Cl)cc1)c1ncc(s1)-c1ccc(Cl)cc1 |TLB:0:1:4.3:7.8.6| |
Structure |
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