| Reaction Details |
|---|
 | Report a problem with these data |
| Target | RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] |
|---|
| Ligand | BDBM372985 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Time-Resolved Fluorescence Energy Transfer Assay |
|---|
| IC50 | 2.50±n/a nM |
|---|
| Citation |  Zhou, C; Wang, S; Zhang, G Fused tricyclic compounds as Raf kinase inhibitors US Patent US9895376 Publication Date 2/20/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] |
|---|
| Name: | RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D] |
|---|
| Synonyms: | C-RAF (Y340D Y341D) | RAF | RAF proto-oncogene serine/threonine-protein kinase (Y340D/Y341D) | RAF proto-oncogene serine/threonine-protein kinase (c-Raf)(Y340D)(Y341D) | RAF1 | RAF1_HUMAN |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 72984.33 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P04049 Y340D Y341D |
|---|
| Residue: | 648 |
|---|
| Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
|
|
|
|---|
| BDBM372985 |
|---|
| n/a |
|---|
| Name | BDBM372985 |
|---|
| Synonyms: | US10576087, Compound 2.5b | US9895376, Compound 2.5b |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H16ClF3N4O3 |
|---|
| Mol. Mass. | 512.868 |
|---|
| SMILES | FC(F)(F)c1cc2[nH]c(nc2cc1Cl)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
