| Reaction Details |
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 | Report a problem with these data |
| Target | AP2-associated protein kinase 1 |
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| Ligand | BDBM373556 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| IC50 | 0.670±n/a nM |
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| Citation |  Luo, G; Chen, L; Dzierba, CD; Ditta, JL; Macor, JE; Bronson, JJ Biaryl kinase inhibitors US Patent US9902722 Publication Date 2/27/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| AP2-associated protein kinase 1 |
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| Name: | AP2-associated protein kinase 1 |
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| Synonyms: | AAK1 | AAK1_HUMAN | Adaptor-associated kinase 1 | KIAA1048 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 103884.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774569 |
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| Residue: | 961 |
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| Sequence: | MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIV
FLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW
EVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE
NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIIT
TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDK
RPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT
ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKP
QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPP
AQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ
QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQ
PKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAA
AEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG
EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFI
PLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPV
PQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNL
ISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLID
L
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| BDBM373556 |
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| n/a |
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| Name | BDBM373556 |
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| Synonyms: | US9902722, Example 29 | methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-chlorophenyl)pyridin-2-yl)carbamate |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26ClN3O3 |
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| Mol. Mass. | 391.892 |
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| SMILES | COC(=O)Nc1cc(ccn1)-c1ccc(OCC(C)(N)CC(C)C)c(Cl)c1 |
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| Structure | 
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