| Reaction Details |
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 | Report a problem with these data |
| Target | Protein Wnt-3a |
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| Ligand | BDBM374997 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Wnt-Luc Reporter Assay |
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| IC50 | 0.200±n/a nM |
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| Citation |  Cheng, D; Gao, W; Han, D; Pan, S; Zhang, G N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as Wnt signaling modulators US Patent US10251893 Publication Date 4/9/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein Wnt-3a |
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| Name: | Protein Wnt-3a |
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| Synonyms: | WNT3A | WNT3A_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39379.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1469237 |
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| Residue: | 352 |
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| Sequence: | MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYV
EIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGV
AFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDAR
SAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASE
MVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVS
SHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
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| BDBM374997 |
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| n/a |
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| Name | BDBM374997 |
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| Synonyms: | N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(4-(2-methylpyrimidin-4-yl)-3-(trifluoromethyl)phenyl)acetamide | US10251893, Cpd 192 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25F3N6O2 |
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| Mol. Mass. | 498.5002 |
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| SMILES | CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2ccc(-c3ccnc(C)n3)c(c2)C(F)(F)F)nc1 |
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| Structure | 
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