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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bcl-2-like protein 1 | ||
| Ligand | BDBM60537 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Lactate Dehydrogenase Inhibition Assay | ||
| IC50 | 390±n/a nM | ||
| Citation |  Choi, SR; Pradhan, A; Hammond, NL; Chittiboyina, AG; Tekwani, BL; Avery, MA Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. J Med Chem50:3841-50 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bcl-2-like protein 1 | |||
| Name: | Bcl-2-like protein 1 | ||
| Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) | ||
| Type: | Mitochondrion membrane; Single-pass membrane protein | ||
| Mol. Mass.: | 26039.60 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 233 | ||
| Sequence: |
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| BDBM60537 | |||
| n/a | |||
| Name | BDBM60537 | ||
| Synonyms: | US9115061, XVII | ||
| Type | n/a | ||
| Emp. Form. | C38H24N2O8S2 | ||
| Mol. Mass. | 700.736 | ||
| SMILES | Cc1cc2c(C(=O)c3nc4ccccc4s3)c(O)c(O)cc2c(O)c1-c1c(C)cc2c(C(=O)c3nc4ccccc4s3)c(O)c(O)cc2c1O |(4,-5.39,;5.33,-4.62,;6.67,-5.39,;8,-4.62,;9.34,-5.39,;9.34,-6.93,;8,-7.7,;10.67,-7.7,;10.91,-9.22,;12.43,-9.46,;13.2,-10.8,;14.74,-10.8,;15.51,-9.46,;14.74,-8.13,;13.2,-8.13,;12.04,-7,;10.67,-4.62,;12,-5.39,;10.67,-3.08,;12,-2.31,;9.34,-2.31,;8,-3.08,;6.67,-2.31,;6.67,-.77,;5.33,-3.08,;4,-2.31,;4,-.77,;5.33,,;2.67,,;1.33,-.77,;;,1.54,;-1.33,2.31,;1.09,2.63,;2.62,2.47,;3.25,3.87,;4.73,4.27,;5.13,5.76,;4.04,6.85,;2.56,6.45,;2.16,4.96,;.77,4.14,;-1.33,-.77,;-2.67,,;-1.33,-2.31,;-2.67,-3.08,;,-3.08,;1.33,-2.31,;2.67,-3.08,;2.67,-4.62,)| | ||
| Structure | 
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