| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase SYK |
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| Ligand | BDBM375970 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Syk Kinase Assay |
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| IC50 | 14.8±n/a nM |
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| Citation |  Dahmann, G; Hoffmann, M; Klicic, J; Lamb, DJ; McCarthy, C; Napier, SC; Parrish, K; Scott, J; Fitzgerald, JL; Walker, E Heteroaryl Syk inhibitors US Patent US9914735 Publication Date 3/13/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase SYK |
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| Name: | Tyrosine-protein kinase SYK |
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| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
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| Type: | Enzyme |
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| Mol. Mass.: | 72079.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43405 |
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| Residue: | 635 |
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| Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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| BDBM375970 |
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| n/a |
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| Name | BDBM375970 |
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| Synonyms: | US10947243, Example 49 | US9914735, Example 49 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H30N6O2 |
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| Mol. Mass. | 422.5233 |
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| SMILES | C[C@@H](Oc1cc(cc2nn(C)cc12)-c1cnn(c1)C1CCN(C)CC1)[C@H]1CNC(=O)C1 |r| |
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| Structure | 
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