| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Chymotrypsin-C |
|---|
| Ligand | BDBM23702 |
|---|
| Substrate/Competitor | BDBM23729 |
|---|
| Meas. Tech. | Human Neutrophil Elastase Inhibition Assay |
|---|
| IC50 | 120±n/a nM |
|---|
| Citation |  Schepetkin, IA; Khlebnikov, AI; Quinn, MT N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem50:4928-38 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Chymotrypsin-C |
|---|
| Name: | Chymotrypsin-C |
|---|
| Synonyms: | CLCR | CTRC | CTRC_HUMAN | Caldecrin | Chymotrypsin | Chymotrypsin C | Chymotrypsin-C |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 29487.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q99895 |
|---|
| Residue: | 268 |
|---|
| Sequence: | MLGITVLAALLACASSCGVPSFPPNLSARVVGGEDARPHSWPWQISLQYLKNDTWRHTCG
GTLIASNFVLTAAHCISNTRTYRVAVGKNNLEVEDEEGSLFVGVDTIHVHKRWNALLLRN
DIALIKLAEHVELSDTIQVACLPEKDSLLPKDYPCYVTGWGRLWTNGPIADKLQQGLQPV
VDHATCSRIDWWGFRVKKTMVCAGGDGVISACNGDSGGPLNCQLENGSWEVFGIVSFGSR
RGCNTRKKPVVYTRVSAYIDWINEKMQL
|
|
|
|---|
| BDBM23702 |
|---|
| BDBM23729 |
|---|
| Name | BDBM23702 |
|---|
| Synonyms: | 3-[(2,4-dimethylphenyl)carbonyl]-1-[(4-fluorophenyl)carbonyl]-1H-pyrazole | N-Benzoylpyrazole deriv., 4 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H15FN2O2 |
|---|
| Mol. Mass. | 322.333 |
|---|
| SMILES | Cc1ccc(C(=O)c2ccn(n2)C(=O)c2ccc(F)cc2)c(C)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
