| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM23732 |
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| Substrate/Competitor | BDBM23699 |
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| Meas. Tech. | Human Neutrophil Elastase Inhibition Assay |
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| Ki | 3100±n/a nM |
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| Citation |  Schepetkin, IA; Khlebnikov, AI; Quinn, MT N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem50:4928-38 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM23732 |
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| BDBM23699 |
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| Name | BDBM23732 |
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| Synonyms: | 3-(2-chlorophenyl)-5-methyl-4-(1H-pyrazol-1-ylcarbonyl)-1,2-oxazole | 3-(2-chlorophenyl)-5-methyl-4-(1H-pyrazol-1-ylcarbonyl)isoxazole | pyrazol-isoxazole, 16 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H10ClN3O2 |
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| Mol. Mass. | 287.701 |
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| SMILES | Cc1onc(c1C(=O)n1cccn1)-c1ccccc1Cl |
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| Structure | 
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