| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Guanylate cyclase soluble subunit alpha-1 |
|---|
| Ligand | BDBM281735 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Stimulation of sGC Enzyme Activity |
|---|
| EC50 | 17.0±n/a nM |
|---|
| Citation |  Hahn, M; Lampe, T; Stasch, J; Schlemmer, K; Wunder, F; Li, VM; Becker-Pelster, E; Stoll, F; Knorr, A; Woltering, E Branched 3-phenylpropionic acid derivatives and their use US Patent US10259776 Publication Date 4/16/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Guanylate cyclase soluble subunit alpha-1 |
|---|
| Name: | Guanylate cyclase soluble subunit alpha-1 |
|---|
| Synonyms: | GCS-alpha-1 | GCS-alpha-3 | GCYA1_HUMAN | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 77457.21 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q02108 |
|---|
| Residue: | 690 |
|---|
| Sequence: | MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLP
QRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAE
QAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAG
KRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCF
HNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQ
FGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKS
SRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQAR
AQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNV
TMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHK
ESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNN
VTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAY
QQGTNSKPCFQKKDVEDGNANFLGKASGID
|
|
|
|---|
| BDBM281735 |
|---|
| n/a |
|---|
| Name | BDBM281735 |
|---|
| Synonyms: | US10023528, Example 12 | US10259776, Example 12 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H26ClF6NO3 |
|---|
| Mol. Mass. | 537.922 |
|---|
| SMILES | CC(C)C(CC(O)=O)c1ccc(Cl)c(NC(=O)C(C(C)C(F)(F)F)c2ccc(CC(F)(F)F)cc2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
