| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Blk |
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| Ligand | BDBM378887 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Inhibition Assays |
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| IC50 | 12.0±n/a nM |
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| Citation |  Yang, S; Wei, Y 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof US Patent US10266537 Publication Date 4/23/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tyrosine-protein kinase Blk |
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| Name: | Tyrosine-protein kinase Blk |
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| Synonyms: | B lymphoid tyrosine kinase | BLK | BLK_HUMAN | SRC | Tyrosine-protein kinase BLK (BLK) | p55-Blk |
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| Type: | Protein |
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| Mol. Mass.: | 57711.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51451 |
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| Residue: | 505 |
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| Sequence: | MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDK
HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLE
MERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR
CLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQS
LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY
AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD
LRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS
FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER
PTFEFLQSVLEDFYTATERQYELQP
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|
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| BDBM378887 |
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| n/a |
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| Name | BDBM378887 |
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| Synonyms: | US10266537, Compound 31 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H26F3N7O |
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| Mol. Mass. | 533.5475 |
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| SMILES | CN1CCC(CC1)n1nc(C#Cc2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)c2c(N)ncnc12 |
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| Structure | 
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