Reaction Details | |||
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Target | Epidermal growth factor receptor | ||
Ligand | BDBM378885 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Inhibition Assays | ||
IC50 | 651±n/a nM | ||
Citation | Yang, S; Wei, Y 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof US Patent US10266537 Publication Date 4/23/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Epidermal growth factor receptor | |||
Name: | Epidermal growth factor receptor | ||
Synonyms: | EGF Receptor Substrate | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal Growth Factor Receptor Tyrosine Kinase | Epidermal Growth Factor Receptor erbB-1 | Epidermal Growth Factor Receptor, ErbB-1 | Epidermal growth factor receptor (EGFR) | Epidermal growth factor receptor (HER1) | HER1 | Protein-Tyrosine Kinase Erbb-1 | Proto-oncogene c-ErbB-1 | Receptor tyrosine-protein kinase ErbB-1 | Tyrosine-Protein Kinase ErbB-1 | ||
Type: | Receptor Kinase Domain | ||
Mol. Mass.: | 134279.59 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P00533 | ||
Residue: | 1210 | ||
Sequence: |
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BDBM378885 | |||
n/a | |||
Name | BDBM378885 | ||
Synonyms: | US10266537, Compound 93 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H27F3N6O2 | ||
Mol. Mass. | 548.5589 | ||
SMILES | Cc1ccc(NC(=O)c2ccc(C)c(c2)C(F)(F)F)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 |r,wU:26.27,wD:29.31,(-5.46,5.4,;-3.98,5.8,;-3.58,7.29,;-2.09,7.69,;-1,6.6,;.49,7,;1.57,5.91,;1.18,4.42,;3.06,6.31,;3.46,7.79,;4.95,8.19,;6.04,7.1,;7.53,7.5,;5.64,5.62,;4.15,5.22,;6.73,4.53,;8.22,4.93,;6.33,3.04,;7.82,3.44,;-1.4,5.11,;-2.89,4.71,;-3.29,3.22,;-3.68,1.74,;-4.08,.25,;-3.18,-1,;-4.08,-2.24,;-3.68,-3.73,;-2.2,-4.13,;-1.8,-5.62,;-2.89,-6.7,;-2.49,-8.19,;-4.38,-6.31,;-4.77,-4.82,;-5.55,-1.77,;-6.88,-2.54,;-8.22,-1.77,;-8.22,-.23,;-6.88,.54,;-6.88,2.08,;-5.55,-.23,)| | ||
Structure |