| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase Src [1-530] |
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| Ligand | BDBM378888 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Inhibition Assays |
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| IC50 | 12.0±n/a nM |
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| Citation |  Yang, S; Wei, Y 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof US Patent US10266537 Publication Date 4/23/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Proto-oncogene tyrosine-protein kinase Src [1-530] |
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| Name: | Proto-oncogene tyrosine-protein kinase Src [1-530] |
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| Synonyms: | Proto-oncogene tyrosine-protein kinase Src (aa 1-530) | SRC | SRC1 | SRC_HUMAN | c-Src (aa 1-530) |
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| Type: | n/a |
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| Mol. Mass.: | 59200.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P12931[1-530] |
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| Residue: | 530 |
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| Sequence: | MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY
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| BDBM378888 |
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| n/a |
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| Name | BDBM378888 |
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| Synonyms: | Preparation of 3-(4-amino-1-(piperidin-4-yl)-1H-pyrazolo [3, 4-d] pyrimidin-3-yl) ethynyl)-4-methyl-((4-methylpiperazin-1-yl) methyl)-3-(trifluoromethyl) phenyl) benzamide | US10266537, Compound 120 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H35F3N8O3 |
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| Mol. Mass. | 648.678 |
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| SMILES | CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3nn(C(=O)OC(C)(C)C)c4ncnc(N)c34)cc2C(F)(F)F)CC1 |
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| Structure | 
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