Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 11 [205-593] |
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Ligand | BDBM24547 |
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Substrate/Competitor | BDBM13432 |
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Meas. Tech. | Phosphatase Activity Assay |
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pH | 7±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 22900±7000 nM |
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Citation | Lawrence, HR; Pireddu, R; Chen, L; Luo, Y; Sung, SS; Szymanski, AM; Yip, ML; Guida, WC; Sebti, SM; Wu, J; Lawrence, NJ Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J Med Chem51:4948-56 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 11 [205-593] |
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Name: | Tyrosine-protein phosphatase non-receptor type 11 [205-593] |
Synonyms: | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein-Tyrosine Phosphatase SHP-2 | SH-PTP3 | SHPTP2 | Shp2 |
Type: | Protein phosphatase |
Mol. Mass.: | 44924.47 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant GST-fusion SHP-2 (205-593). |
Residue: | 389 |
Sequence: | TLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYS
RKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPK
KSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMR
VRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLE
EVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQ
RSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPL
PPCTPTPPCAEMREDSARVYENVGLMQQQ
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BDBM24547 |
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BDBM13432 |
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Name | BDBM24547 |
Synonyms: | 2-{2-[(3Z)-5-({[4-chloro-3-(trifluoromethyl)phenyl]methyl}sulfamoyl)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]hydrazin-1-yl}benzoic acid | Oxindole scaffold, 10l |
Type | Small organic molecule |
Emp. Form. | C23H16ClF3N4O5S |
Mol. Mass. | 552.91 |
SMILES | OC(=O)c1ccccc1NN=C1C(=O)Nc2ccc(cc12)S(=O)(=O)NCc1ccc(Cl)c(c1)C(F)(F)F |w:10.10| |
Structure |
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