| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 11 [205-593] |
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| Ligand | BDBM24550 |
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| Substrate/Competitor | BDBM13432 |
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| Meas. Tech. | Phosphatase Activity Assay |
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| pH | 7±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 4800±600 nM |
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| Citation |  Lawrence, HR; Pireddu, R; Chen, L; Luo, Y; Sung, SS; Szymanski, AM; Yip, ML; Guida, WC; Sebti, SM; Wu, J; Lawrence, NJ Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J Med Chem51:4948-56 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 11 [205-593] |
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| Name: | Tyrosine-protein phosphatase non-receptor type 11 [205-593] |
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| Synonyms: | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein-Tyrosine Phosphatase SHP-2 | SH-PTP3 | SHPTP2 | Shp2 |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 44924.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant GST-fusion SHP-2 (205-593). |
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| Residue: | 389 |
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| Sequence: | TLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYS
RKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPK
KSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMR
VRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLE
EVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQ
RSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPL
PPCTPTPPCAEMREDSARVYENVGLMQQQ
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| BDBM24550 |
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| BDBM13432 |
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| Name | BDBM24550 |
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| Synonyms: | 3-{2-[(3Z)-5-{[(3-chloro-4-fluorophenyl)methyl]sulfamoyl}-2-oxo-2,3-dihydro-1H-indol-3-ylidene]hydrazin-1-yl}benzoic acid | Oxindole scaffold, 10o |
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| Type | Small organic molecule |
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| Emp. Form. | C22H16ClFN4O5S |
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| Mol. Mass. | 502.903 |
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| SMILES | OC(=O)c1cccc(NN=C2C(=O)Nc3ccc(cc23)S(=O)(=O)NCc2ccc(F)c(Cl)c2)c1 |w:9.8| |
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| Structure | 
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