| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 6 [205-595] |
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| Ligand | BDBM24537 |
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| Substrate/Competitor | BDBM13432 |
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| Meas. Tech. | Phosphatase Activity Assay |
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| pH | 7±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 27700±9000 nM |
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| Citation |  Lawrence, HR; Pireddu, R; Chen, L; Luo, Y; Sung, SS; Szymanski, AM; Yip, ML; Guida, WC; Sebti, SM; Wu, J; Lawrence, NJ Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J Med Chem51:4948-56 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 6 [205-595] |
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| Name: | Tyrosine-protein phosphatase non-receptor type 6 [205-595] |
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| Synonyms: | HCP | Hematopoietic cell protein-tyrosine phosphatase | PTN6_HUMAN | PTP-1C | PTP1C | PTPN6 | Protein-Tyrosine Phosphatase SHP-1 | Protein-tyrosine phosphatase 1C | SH-PTP1 | Tyrosine-protein phosphatase non-receptor type 6 |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 44886.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant GST-fusion SHP-1 (205-595). |
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| Residue: | 391 |
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| Sequence: | AFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLE
GQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIAS
QGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGE
HDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLP
HAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQ
YKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVY
ENLHTKNKREEKVKKQRSADKEKSKGSLKRK
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| BDBM24537 |
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| BDBM13432 |
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| Name | BDBM24537 |
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| Synonyms: | 4-{2-[(3Z)-2-oxo-5-(propan-2-ylsulfamoyl)-2,3-dihydro-1H-indol-3-ylidene]hydrazin-1-yl}benzoic acid | Oxindole scaffold, 10b |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18N4O5S |
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| Mol. Mass. | 402.424 |
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| SMILES | CC(C)NS(=O)(=O)c1ccc2NC(=O)C(=NNc3ccc(cc3)C(O)=O)c2c1 |w:15.15| |
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| Structure | 
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