Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM382333

Substrate/Competitor

n/a

Meas. Tech.

Inhibition Assay

1.26±n/a nM

Citation

Micheli, F; Cremonesi, S; Semeraro, T; Tarsi, L Substituted hexahydropyrrolo[3,4-b]pyrroles and hexahydrocyclopenta[c]pyrroles as dopamine receptor modulators US Patent US10273244 Publication Date 4/30/2019

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

Type:

n/a

Mol. Mass.:

44243.43

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

400

Sequence:

MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

BDBM382333

n/a

Name

BDBM382333

Synonyms:

US10273244, Example 218

Type

Small organic molecule

Emp. Form.

C25H34F3N5OS

Mol. Mass.

509.631

SMILES

Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)nnc1C1CCC(O)CC1 |w:27.31,31.35,(3.57,.14,;3.97,1.63,;3.07,2.88,;1.58,2.48,;.49,3.57,;-1,3.17,;-2.09,4.26,;-3.57,3.86,;-4.48,5.11,;-5.94,4.63,;-7.41,5.11,;-8.31,3.86,;-7.41,2.61,;-5.94,3.09,;-4.48,2.61,;-7.81,1.13,;-9.29,.73,;-9.69,-.76,;-8.64,-1.99,;-7.12,-1.45,;-6.72,.04,;-9.04,-3.47,;-9.44,-4.96,;-10.53,-3.08,;-7.55,-3.87,;3.97,4.12,;5.44,3.65,;5.44,2.11,;6.77,1.34,;6.77,-.2,;8.1,-.97,;9.44,-.2,;10.77,-.97,;9.44,1.34,;8.1,2.11,)|

Structure