Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM382335

Substrate/Competitor

n/a

Meas. Tech.

Inhibition Assay

1.10±n/a nM

Citation

Micheli, F; Cremonesi, S; Semeraro, T; Tarsi, L Substituted hexahydropyrrolo[3,4-b]pyrroles and hexahydrocyclopenta[c]pyrroles as dopamine receptor modulators US Patent US10273244 Publication Date 4/30/2019

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

Type:

n/a

Mol. Mass.:

44243.43

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

400

Sequence:

MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

BDBM382335

n/a

Name

BDBM382335

Synonyms:

US10273244, Example 221

Type

Small organic molecule

Emp. Form.

C25H34F3N5OS

Mol. Mass.

509.631

SMILES

Cn1c(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccc(cc2)C(F)(F)F)nnc1C1CCC(O)CC1 |r,w:27.31,31.35,wD:9.8,13.12,(3.57,-.39,;3.97,1.1,;3.07,2.35,;1.58,1.95,;.49,3.04,;-1,2.64,;-2.09,3.73,;-3.57,3.33,;-4.48,4.57,;-5.94,4.1,;-7.41,4.57,;-8.31,3.33,;-7.41,2.08,;-5.94,2.56,;-4.48,2.08,;-7.81,.6,;-9.29,.2,;-9.69,-1.29,;-8.62,-2.43,;-7.12,-1.98,;-6.72,-.49,;-9.02,-3.92,;-9.42,-5.41,;-10.5,-3.52,;-7.53,-4.32,;3.97,3.59,;5.44,3.12,;5.44,1.58,;6.77,.81,;6.77,-.73,;8.1,-1.5,;9.44,-.73,;10.77,-1.5,;9.44,.81,;8.1,1.58,)|

Structure