| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Genome polyprotein |
|---|
| Ligand | BDBM263095 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Norovirus Polymerase Inhibition Assay |
|---|
| EC50 | >100000±n/a nM |
|---|
| Citation |  Bougher, III, JH; Changalvala, RV; Downey, AL; Drach, JC; Lanier, Jr., ER; McIver, AL; Robertson, BD; Selleseth, DW; Sethna, PB; Townsend, L; Ware, RW Pyrrolopyrimidine nucleosides and analogs thereof US Patent US9708359 Publication Date 7/18/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Genome polyprotein |
|---|
| Name: | Genome polyprotein |
|---|
| Synonyms: | Norovirus Polymerase |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 187250.43 |
|---|
| Organism: | Murine norovirus 1 |
|---|
| Description: | Q80J95 |
|---|
| Residue: | 1685 |
|---|
| Sequence: | MRMATPSSAPSVRNTEKRKNKKASSKASVSFGAPSPLSSESEDEINYMTPPEQEAQPGAL
AALHAEGPLAGLPVTRSDARVLIFNEWEERKKSDPWLRLDMSDKAIFRRYPHLRPKEDRP
DAPSHAEDAMDAKEPVIGSILEQDDHKFYHYSVYIGGGLVMGVNNPSAAVCQATIDVEKL
HLWWRPVWEPRPLDSAELRKCVGMTVPYVATTVNCYQVCCWIVGIKDTWLKRAKISRDLP
FYSPVQDWNVDPQEPFIPSKLRMVSDGILVALSAVIGRPIKNLLASVKPLNILNIVLSCD
WTFSGIVNALILLAELFDIFWTPPDVTNWMISIFGEWQAEGPFDLALDVVPTLLGGIGMA
FGLTSETIGRKLASTNSALKAAQEMGKFAIEVFKQIMAWIWPSEDPVPALLSNMEQAIIK
NECQLENQLTAMLRDRNAGAEFLRSLDEEEQEVRKIAAKCGNSATTGTTNALLARISMAR
AAFEKARAEQTSRVRPVVIMVSGRPGIGKTCFCQNLAKRIAASLGDETSVGIIPRADVDH
WDAYKGARVVLWDDFGMDNVVKDALRLQMLADTCPVTLNCDRIENKGKMFDSQVIIITTN
QQTPVPLDYVNLEAVCRRIDFLVYAESPVVDDARARAPGDVNAVKAAMRPDYSHINFILA
PQGGFDRQGNTPYGKGVTKIIGATALCARAVALVHERHDDFGLQNKVYDFDAGKVTAFKA
MAADAGIPWYKMAAIGCKAMGCTCVEEAMHLLKDYEVAPCQVIYNGATYNVSCIKGAPMV
EKVKEPELPKTLVNCVRRIKEARLRCYCRMAADVITSILQAAGTAFSIYHQIEKRSRPSF
YWDGYTYRDGPGSFDIFEDDDDGWYHSEGKKGKNKKGRGRPGVFRTRGLTDEEYDEFKKR
RESRGGKYSIDDYLADREREEELLERDEEEAIFGDGFGLKATRRSRKAERAKLGLVSGGD
IRARKPIDWNVVGPSWADDDRQVDYGEKINFEAPVSIWSRVVQFGTGWGFWVSGHVFITA
KHVAPPKGTEIFGRKPGDFTVTSSGDFLKYYFTSAVRPDIPAMVLENGCQEGVVASVLVK
RASGEMLALAVRMGSQAAIKIGSAVVHGQTGMLLTGSNAKAQDLGTIPGDCGCPYVYKKG
NTWVVIGVHVAATRSGNTVIAATHGEPTLEALEFQGPPMLPRPSGTYAGLPIADYGDAPP
LSTKTMFWRTSPEKLPPGAWEPAYLGSKDERVDGPSLQQVMRDQLKPYSEPRGLLPPQEI
LDAVCDAIENRLENTLEPQKPWTFKKACESLDKNTSSGYPYHKQKSKDWTGSAFIGDLGD
QATHANNMYEMGKSMRPIYTAALKDELVKPDKIYGKIKKRLLWGSDLGTMIRAARAFGPF
CDALKETCIFNPIRVGMSMNEDGPFIFARHANFRYHMDADYTRWDSTQQRAILKRAGDIM
VRLSPEPDLARVVMDDLLAPSLLDVGDYKIVVEEGLPSGCPCTTQLNSLAHWILTLCAMV
EVTRVDPDIVMQESEFSFYGDDEVVSTNLELDMVKYTMALRRYGLLPTRADKEEGPLERR
QTLQGISFLRRAIVGDQFGWYGRLDRASIDRQLLWTKGPNHQNPFETLPGHAQRPSQLMA
LLGEAAMHGEKYYRTVASRVSKEAAQSGIEMVVPRHRSVLRWVRFGTMDAETPQERSAVF
VNEDE
|
|
|
|---|
| BDBM263095 |
|---|
| n/a |
|---|
| Name | BDBM263095 |
|---|
| Synonyms: | US9708359, 16 | US9708359, 28 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H19N5O4S |
|---|
| Mol. Mass. | 401.44 |
|---|
| SMILES | NC(=S)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(nc(N)c12)-c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
