| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform 2 of Nuclear receptor ROR-gamma (RORgT) |
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| Ligand | BDBM392173 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | RORgamma Gal4 Reporter Gene Assay (REN) |
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| IC50 | 3.98±n/a nM |
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| Citation |  Gege, C; Steeneck, C; Kinzel, O; Kleymann, G; Hoffmann, T Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR[γ] US Patent US10301272 Publication Date 5/28/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform 2 of Nuclear receptor ROR-gamma (RORgT) |
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| Name: | Isoform 2 of Nuclear receptor ROR-gamma (RORgT) |
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| Synonyms: | Isoform 2 of Nuclear receptor ROR-gamma | NR1F3 | Nuclear receptor ROR-gamma (RORgT) | Nuclear receptor ROR-gammaT | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma (RORgT) | Retinoid-related orphan receptor-gamma (RORĪ³T) |
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| Type: | Protein |
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| Mol. Mass.: | 55831.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51449-2 |
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| Residue: | 497 |
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| Sequence: | MRTQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRN
RCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGA
QGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCH
LEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPE
APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCA
HHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGK
YGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQ
LQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPL
YKELFSTETESPVGLSK
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| BDBM392173 |
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| n/a |
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| Name | BDBM392173 |
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| Synonyms: | US10301272, Example 21/4 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H36ClF2N3O5S2 |
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| Mol. Mass. | 608.161 |
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| SMILES | CC(C)(O)CNC(=O)c1nc(CC2CCCCC2)c(s1)-c1ccc(c(Cl)c1OC(F)F)S(=O)(=O)NC(C)(C)C |
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| Structure | 
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