| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 2 |
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| Ligand | BDBM393732 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro GIRK Thallium Flux Assay (2.5 minutes) |
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| EC50 | 420±n/a nM |
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| Citation |  Cosford, ND; Raveendra-Panickar, D; Sheffler, DJ Metabotropic glutamate receptor negative allosteric modulators (NAMS) and uses thereof US Patent US9969726 Publication Date 5/15/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 2 |
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| Name: | Metabotropic glutamate receptor 2 |
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| Synonyms: | GRM2_RAT | Gprc1b | Grm2 | Mglur2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95786.41 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_105034 |
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| Residue: | 872 |
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| Sequence: | MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGAL
ESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAP
RASANLGQGSGSQFVPTVCNGREVVDSTTSSL
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| BDBM393732 |
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| n/a |
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| Name | BDBM393732 |
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| Synonyms: | US10597367, Example 28 | US9969726, Example 22 | US9969726, Example 28 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H15NS |
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| Mol. Mass. | 313.416 |
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| SMILES | c1sc(nc1-c1cccc(c1)-c1ccccc1)-c1ccccc1 |
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| Structure | 
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