| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Pantetheinase |
|---|
| Ligand | BDBM395055 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Human Vanin-1 Enzyme Assay 3 |
|---|
| IC50 | 10.6±n/a nM |
|---|
| Citation |  Casimiro-Garcia, A; Condon, JS; Flick, AC; Gopalsamy, A; Kirincich, SJ; Mathias, JP; Strobach, JW; Xiang, JS; Xing, LH; Wang, X Heterocyclic compounds as inhibitors of Vanin-1 enzyme US Patent US10308615 Publication Date 6/4/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Pantetheinase |
|---|
| Name: | Pantetheinase |
|---|
| Synonyms: | Pantetheine hydrolase | Tiff66 | VNN1 | VNN1_HUMAN | Vanin-1 | Vascular non-inflammatory molecule 1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 57002.46 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O95497 |
|---|
| Residue: | 513 |
|---|
| Sequence: | MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDIL
EGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPV
QERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQN
LFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMN
VLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLL
LSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKD
LCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETAST
RFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLY
EKDWASNASSGLTAQARIIMLIVIAPIVCSLSW
|
|
|
|---|
| BDBM395055 |
|---|
| n/a |
|---|
| Name | BDBM395055 |
|---|
| Synonyms: | US10308615, Example 66 | {2-[(1- phenylcyclopropyl) amino]pyrimidin- 5-yl}[3- (trifluoromethyl) phenyl]methanone |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H16F3N3O |
|---|
| Mol. Mass. | 383.3664 |
|---|
| SMILES | FC(F)(F)c1cccc(c1)C(=O)c1cnc(NC2(CC2)c2ccccc2)nc1 |
|---|
| Structure | 
|
|---|
Search and Browse
