Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase receptor TYRO3

Ligand

BDBM396966

Substrate/Competitor

n/a

Meas. Tech.

Enzymatic Assay

IC50

>100±n/a nM

Citation

Li, Y; Wang, X; He, C Pyrrolotriazine compounds as tam inhibitors US Patent US9981975 Publication Date 5/29/2018

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase receptor TYRO3

Name:

Tyrosine-protein kinase receptor TYRO3

Synonyms:

BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY

Type:

Protein

Mol. Mass.:

96894.13

Organism:

Homo sapiens (Human)

Description:

Q06418

Residue:

890

Sequence:

MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV
KLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVE
DGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI
GGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSN
ASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRC
ANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKL
SWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQ
GPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAA
RSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE
DGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPM
VILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARN
CMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGV
TMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT
CLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAV
GGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC

BDBM396966

n/a

Name

BDBM396966

Synonyms:

N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]phenyl}-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide | US10442810, Example 28 | US10844069, Example 28 | US11591338, Example 28 | US9981975, Example 28

Type

Small organic molecule

Emp. Form.

C31H27N7O2

Mol. Mass.

529.5918

SMILES

Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:32.36,35.43,(-5.98,13.04,;-6.45,11.58,;-7.96,11.26,;-8.44,9.79,;-7.41,8.65,;-5.9,8.97,;-4.65,8.06,;-3.41,8.97,;-3.88,10.43,;-3.11,11.76,;-1.57,11.76,;-.8,13.1,;-1.57,14.43,;-.8,15.77,;.74,15.77,;1.51,14.43,;1.51,17.1,;.74,18.43,;1.51,19.77,;3.05,19.77,;3.82,18.43,;5.36,18.43,;6.13,17.1,;7.67,17.1,;8.44,18.43,;7.67,19.77,;6.13,19.77,;3.05,17.1,;3.82,15.77,;-3.11,14.43,;-3.88,13.1,;-5.42,10.43,;-4.65,6.52,;-5.99,5.75,;-5.99,4.21,;-4.65,3.44,;-3.32,4.21,;-3.32,5.75,;-4.65,1.9,;-4.65,.36,)|

Structure