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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM396968 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Assay | ||
| IC50 | <5±n/a nM | ||
| Citation |  Li, Y; Wang, X; He, C Pyrrolotriazine compounds as tam inhibitors US Patent US9981975 Publication Date 5/29/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM396968 | |||
| n/a | |||
| Name | BDBM396968 | ||
| Synonyms: | N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-3-fluorophenyl}-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide | US10442810, Example 30 | US10844069, Example 30 | US11591338, Example 30 | US9981975, Example 30 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C31H26FN7O2 | ||
| Mol. Mass. | 547.5822 | ||
| SMILES | Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)[C@@H]1CC[C@@H](CC1)C#N |r,wU:33.37,36.44,(-5.98,13.38,;-6.45,11.92,;-7.96,11.6,;-8.44,10.13,;-7.41,8.99,;-5.9,9.31,;-4.65,8.4,;-3.41,9.31,;-3.88,10.77,;-3.11,12.11,;-3.88,13.44,;-3.11,14.78,;-1.57,14.78,;-.8,16.11,;.74,16.11,;1.51,14.78,;1.51,17.44,;.74,18.78,;1.51,20.11,;3.05,20.11,;3.82,18.78,;5.36,18.78,;6.13,17.44,;7.67,17.44,;8.44,18.78,;7.67,20.11,;6.13,20.11,;3.05,17.44,;3.82,16.11,;-.8,13.44,;-1.57,12.11,;-.8,10.77,;-5.42,10.77,;-4.65,6.86,;-5.99,6.09,;-5.99,4.55,;-4.65,3.78,;-3.32,4.55,;-3.32,6.09,;-4.65,2.24,;-4.65,.7,)| | ||
| Structure | 
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