| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-3/beta-2 |
|---|
| Ligand | BDBM397484 |
|---|
| Substrate/Competitor | n/a |
|---|
| Ki | 230±n/a nM |
|---|
| Citation |  Xiao, Y; Kellar, KJ; Brown, ML; Paige, MA; Liu, Y; Levin, ED; Rezvani, AH 2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof US Patent US9993465 Publication Date 6/12/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuronal acetylcholine receptor subunit alpha-3/beta-2 |
|---|
| Name: | Neuronal acetylcholine receptor subunit alpha-3/beta-2 |
|---|
| Synonyms: | Neuronal acetylcholine receptor Alpha-3/Beta-2 | Neuronal acetylcholine receptor protein alpha-3/beta-2 subunit | Neuronal acetylcholine receptor; alpha3/beta2 | nAChR subtypes alpha3 beta2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Neuronal acetylcholine receptor subunit alpha-3 |
|---|
| Synonyms: | ACHA3_RAT | Acra3 | Chrna3 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56995.52 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P04757 |
|---|
| Residue: | 499 |
|---|
| Sequence: | MGVVLLPPPLSMLMLVLMLLPAASASEAEHRLFQYLFEDYNEIIRPVANVSHPVIIQFEV
SMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNN
ADGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAK
IDLVLIGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTI
NLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGE
YLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSGEGDT
PKTRTFYGAELSNLNCFSRADSKSCKEGYPCQDGTCGYCHHRRVKISNFSANLTRSSSSE
SVNAVLSLSALSPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILV
CILGTAGLFLQPLMARDDT
|
|
|
|---|
| Component 2 |
| Name: | Neuronal acetylcholine receptor subunit beta-2 |
|---|
| Synonyms: | ACHB2_RAT | Acrb2 | Chrnb2 | N-alpha 1 | Neuronal acetylcholine receptor non-alpha-1 chain |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56910.32 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P12390 |
|---|
| Residue: | 500 |
|---|
| Sequence: | MAGHSNSMALFSFSLLWLCSGVLGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLM
VSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLYN
NADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRT
EIDLVLKSDVASLDDFTPSGEWDIIALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINL
IIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYL
MFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPTLLFLQQPRHRCARQRL
RLRRRQREREGAGALFFREGPAADPCTCFVNPASVQGLAGAFRAEPTAAGPGRSVGPCSC
GLREAVDGVRFIADHMRSEDDDQSVREDWKYVAMVIDRLFLWIFVFVCVFGTVGMFLQPL
FQNYTATTFLHPDHSAPSSK
|
|
|
|---|
| BDBM397484 |
|---|
| n/a |
|---|
| Name | BDBM397484 |
|---|
| Synonyms: | US9993465, (S)-22 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H21FN2O |
|---|
| Mol. Mass. | 276.3491 |
|---|
| SMILES | Cc1ncc(cc1OCC1CCN1)C#CCCCCF |
|---|
| Structure | 
|
|---|
Search and Browse
