Reaction Details |
| Report a problem with these data |
Target | A disintegrin and metalloproteinase with thrombospondin motifs 4 |
---|
Ligand | BDBM50345522 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Immunoblotting |
---|
IC50 | 16.0±n/a nM |
---|
Citation | Vistnes, M; Christensen, G; Aronsen, M; Lunde, IG; Sjaastad, I; Carlson, CR Inhibitors of ADAMTS4 or ADAMTS5 for use in preventing or treating cardiac remodeling and chronic heart failure US Patent US10322143 Publication Date 6/18/2019 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
A disintegrin and metalloproteinase with thrombospondin motifs 4 |
---|
Name: | A disintegrin and metalloproteinase with thrombospondin motifs 4 |
Synonyms: | A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) | ADAMTS4 | ATS4_HUMAN | Aggrecanase-1 | KIAA0688 | Metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) |
Type: | Enzyme |
Mol. Mass.: | 90214.54 |
Organism: | Homo sapiens (Human) |
Description: | O75173 |
Residue: | 837 |
Sequence: | MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEE
IVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLG
GAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHI
LRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKR
YLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLN
TPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAA
HELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGY
GHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHA
MCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGV
QFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSF
PGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHA
GCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNP
GHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQP
LTLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQDWLHRRAQILEILRRRPWAGRK
|
|
|
BDBM50345522 |
---|
n/a |
---|
Name | BDBM50345522 |
Synonyms: | CHEMBL1784347 | N-(4-{4-[2-(3,5-Dimethyl-isoxazol-4-yl)-ethyl]-piperidine-1-sulfonylmethyl}-1,1-dioxo-hexahydro-1lambda*6*-thiopyran-4-yl)-N-hydroxy-formamide | US10322143, Compound 14g |
Type | Small organic molecule |
Emp. Form. | C19H31N3O7S2 |
Mol. Mass. | 477.595 |
SMILES | Cc1noc(C)c1CCC1CCN(CC1)S(=O)(=O)CC1(CCS(=O)(=O)CC1)N(O)C=O |
Structure |
|