| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dimer of Gag-Pol polyprotein [501-599] |
|---|
| Ligand | BDBM32391 |
|---|
| Substrate/Competitor | HIV-1 PR Substrate Peptide |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| pH | 5.5±n/a |
|---|
| Temperature | 296.15±n/a K |
|---|
| Ki | 900±n/a nM |
|---|
| Km | 14600±n/a nM |
|---|
| Citation |  Blum, A; Böttcher, J; Sammet, B; Luksch, T; Heine, A; Klebe, G; Diederich, WE Achiral oligoamines as versatile tool for the development of aspartic protease inhibitors. Bioorg Med Chem16:8574-86 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
|---|
| |
| Dimer of Gag-Pol polyprotein [501-599] |
|---|
| Name: | Dimer of Gag-Pol polyprotein [501-599] |
|---|
| Synonyms: | HIV-1 Protease | HIV-1 Protease, recombinant, isolate HXB2 |
|---|
| Type: | Protein Complex |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Gag-Pol polyprotein [501-599] |
|---|
| Synonyms: | BRU isolated | HIV-1 Protease B Subtype Chain A | HIV-1 Protease B Subtype Chain B | HIV-1 Protease chain A | LAI(Wild type) | POL_HV1BR | Protease Retropepsin | gag-pol |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 10795.19 |
|---|
| Organism: | Human immunodeficiency virus type 1 |
|---|
| Description: | P03367[501-599] |
|---|
| Residue: | 99 |
|---|
| Sequence: | PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
|
|
|---|
| Component 2 |
| Name: | Gag-Pol polyprotein [501-599] |
|---|
| Synonyms: | BRU isolated | HIV-1 Protease B Subtype Chain A | HIV-1 Protease B Subtype Chain B | HIV-1 Protease chain A | LAI(Wild type) | POL_HV1BR | Protease Retropepsin | gag-pol |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 10795.19 |
|---|
| Organism: | Human immunodeficiency virus type 1 |
|---|
| Description: | P03367[501-599] |
|---|
| Residue: | 99 |
|---|
| Sequence: | PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
|
|
|---|
| BDBM32391 |
|---|
| HIV-1 PR Substrate Peptide |
|---|
| Name: | HIV-1 PR Substrate Peptide |
|---|
| Synonyms: | n/a |
|---|
| Type: | fluorogenic substrate |
|---|
| Mol. Mass.: | 2590.28 |
|---|
| Organism: | n/a |
|---|
| Description: | n/a |
|---|
| Residue: | 23 |
|---|
| Sequence: | Abz-Thr-Ile-Nle-(p-NO2-Phe)-Gln-Arg-NH2
|
|
|
|---|
Search and Browse
