Reaction Details |
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Target | Interleukin-1 beta |
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Ligand | BDBM398083 |
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Substrate/Competitor | n/a |
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Meas. Tech. | IL-1beta release assay |
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IC50 | 300±n/a nM |
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Citation | Karra, SR Indole derivatives and their use in neurodegenerative diseases US Patent US10323000 Publication Date 6/18/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Interleukin-1 beta |
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Name: | Interleukin-1 beta |
Synonyms: | IL1B | IL1B_HUMAN | IL1F2 | Interleukin 1-beta | Interleukin-1 beta | hIL-1beta |
Type: | Cytokine |
Mol. Mass.: | 30734.47 |
Organism: | Homo sapiens (Human) |
Description: | P01584 |
Residue: | 269 |
Sequence: | MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG
FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR
SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE
KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST
SQAENMPVFLGGTKGGQDITDFTMQFVSS
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BDBM398083 |
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n/a |
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Name | BDBM398083 |
Synonyms: | 4-Chloro-1-(2-methoxy-ethyl)-1H-indole-3-carboxylic acid (1-hydroxy-cyclohexyl methyl)-amide | US10323000, Compound 19 | US10676433, Compound 19 |
Type | Small organic molecule |
Emp. Form. | C19H25ClN2O3 |
Mol. Mass. | 364.866 |
SMILES | COCCn1cc(C(=O)NCC2(O)CCCCC2)c2c(Cl)cccc12 |
Structure |
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