| Reaction Details |
|---|
 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
|---|
| Ligand | BDBM398094 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Pore Permeation Assay |
|---|
| IC50 | 300±n/a nM |
|---|
| Citation |  Karra, SR Indole derivatives and their use in neurodegenerative diseases US Patent US10323000 Publication Date 6/18/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| P2X purinoceptor 7 |
|---|
| Name: | P2X purinoceptor 7 |
|---|
| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68602.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q99572 |
|---|
| Residue: | 595 |
|---|
| Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
|
|
|
|---|
| BDBM398094 |
|---|
| n/a |
|---|
| Name | BDBM398094 |
|---|
| Synonyms: | 4-Chloro-1-(2-methoxy-ethyl)-1H-indole-3-carboxylic acid chroman-3-ylamide | US10323000, Compound 29 | US10676433, Compound 29 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H21ClN2O3 |
|---|
| Mol. Mass. | 384.856 |
|---|
| SMILES | COCCn1cc(C(=O)NC2COc3ccccc3C2)c2c(Cl)cccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
