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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | P2X purinoceptor 7 | ||
| Ligand | BDBM398119 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Pore Permeation Assay | ||
| IC50 | 55±n/a nM | ||
| Citation |  Karra, SR Indole derivatives and their use in neurodegenerative diseases US Patent US10323000 Publication Date 6/18/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| P2X purinoceptor 7 | |||
| Name: | P2X purinoceptor 7 | ||
| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor | ||
| Type: | Protein | ||
| Mol. Mass.: | 68602.85 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q99572 | ||
| Residue: | 595 | ||
| Sequence: |
| ||
| BDBM398119 | |||
| n/a | |||
| Name | BDBM398119 | ||
| Synonyms: | 4-Chloro-1-oxetan-3-yl-1H-indole-3-carboxylic acid (4-trifluoromethyl-cyclohexylmethyl)-amide | US10323000, Compound 53 | US10676433, Compound 53 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H22ClF3N2O2 | ||
| Mol. Mass. | 414.849 | ||
| SMILES | FC(F)(F)C1CCC(CNC(=O)c2cn(C3COC3)c3cccc(Cl)c23)CC1 |(6.53,3.69,;5.44,4.78,;5.84,6.27,;6.93,5.18,;3.95,4.38,;3.55,2.9,;2.07,2.5,;.98,3.59,;-.51,3.19,;-.91,1.7,;-2.4,1.3,;-3.49,2.39,;-2.8,-.19,;-1.89,-1.43,;-2.8,-2.68,;-2.4,-4.17,;-3.17,-5.5,;-1.83,-6.27,;-1.06,-4.94,;-4.26,-2.2,;-5.59,-2.97,;-6.93,-2.2,;-6.93,-.66,;-5.59,.11,;-5.59,1.65,;-4.26,-.66,;1.38,5.07,;2.86,5.47,)| | ||
| Structure | 
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