Reaction Details |
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Target | Sortase family protein |
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Ligand | BDBM33365 |
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Substrate/Competitor | BDBM33299 |
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Meas. Tech. | Fluorescence Resonance Energy Transfer (FRET) Assay |
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IC50 | 8900±n/a nM |
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Citation | Suree, N; Yi, SW; Thieu, W; Marohn, M; Damoiseaux, R; Chan, A; Jung, ME; Clubb, RT Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors. Bioorg Med Chem17:7174-85 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Sortase family protein |
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Name: | Sortase family protein |
Synonyms: | Sortase | Sortase A (SrtA) |
Type: | Enzyme |
Mol. Mass.: | 23546.15 |
Organism: | Staphylococcus aureus |
Description: | n/a |
Residue: | 206 |
Sequence: | MKKWTNRLMTIAGVVLILVAAYLFAKPHIDNYLHDKDKDEKIEQYDKNVKEQASKDKKQQ
AKPQIPKDKSKVAGYIEIPDADIKEPVYPGPATPEQLNRGVSFAEENESLDDQNISIAGH
TFIDRPNYQFTNLKAAKKGSMVYFKVGNETRKYKMTSIRDVKPTDVGVLDEQKGKDKQLT
LITCDDYNEKTGVWEKRKIFVATEVK
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BDBM33365 |
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BDBM33299 |
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Name | BDBM33365 |
Synonyms: | pyrazolethione, 3-3 |
Type | Small organic molecule |
Emp. Form. | C17H13BrN4O2S |
Mol. Mass. | 417.28 |
SMILES | Cc1[nH]n(-c2ccccc2)c(=S)c1C=Nc1ccc(cc1Br)[N+]([O-])=O |w:13.14| |
Structure |
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