| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 [828-1132] |
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| Ligand | BDBM400394 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro JAK Kinase Assay |
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| IC50 | <5±n/a nM |
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| Citation |  Huang, T; Xue, C Piperidin-4-yl azetidine derivatives as JAK1 inhibitors US Patent US9999619 Publication Date 6/19/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK2 [828-1132] |
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| Name: | Tyrosine-protein kinase JAK2 [828-1132] |
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| Synonyms: | JAK2 | JAK2 (aa 828-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 |
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| Type: | n/a |
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| Mol. Mass.: | 35579.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60674[828-1132] |
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| Residue: | 305 |
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| Sequence: | GALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS
TEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKER
IDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEY
YKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGN
DKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIR
DNMAG
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|
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| BDBM400394 |
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| n/a |
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| Name | BDBM400394 |
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| Synonyms: | Diastereomers of {1-[1-(3-fluorobenzoyl)-2-methylpiperidin-4-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile | US10695337, Example 150 | US9999619, Example 149 | US9999619, Example 150 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27FN8O |
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| Mol. Mass. | 498.5547 |
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| SMILES | CC1CC(CCN1C(=O)c1cccc(F)c1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 |
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| Structure | 
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