| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 [828-1132] |
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| Ligand | BDBM400412 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro JAK Kinase Assay |
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| IC50 | <5±n/a nM |
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| Citation |  Huang, T; Xue, C Piperidin-4-yl azetidine derivatives as JAK1 inhibitors US Patent US9999619 Publication Date 6/19/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK2 [828-1132] |
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| Name: | Tyrosine-protein kinase JAK2 [828-1132] |
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| Synonyms: | JAK2 | JAK2 (aa 828-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 |
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| Type: | n/a |
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| Mol. Mass.: | 35579.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60674[828-1132] |
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| Residue: | 305 |
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| Sequence: | GALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS
TEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKER
IDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEY
YKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGN
DKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIR
DNMAG
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| BDBM400412 |
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| n/a |
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| Name | BDBM400412 |
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| Synonyms: | US10695337, Example 167 | US11285140, Example 167 | US9999619, Example 167 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H26F3N9O |
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| Mol. Mass. | 549.5502 |
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| SMILES | FC(F)(F)c1ccc(NC(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)cc1 |
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| Structure | 
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