Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM401850 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FLIPR Ca2+ Flux Assay |
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IC50 | 3060±n/a nM |
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Citation | Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N Pyrazole, triazole and tetrazole orexin receptor antagonists US Patent US10010539 Publication Date 7/3/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
Type: | Protein |
Mol. Mass.: | 47554.50 |
Organism: | Homo sapiens (Human) |
Description: | O43613 |
Residue: | 425 |
Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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BDBM401850 |
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n/a |
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Name | BDBM401850 |
Synonyms: | 2-{2-[(3R,6R)-1-{[2- (Difluoromethoxy)phenyl] carbonyl}-6-methylpiperidin-3- yl]-5-methyl-2H-1,2,3-triazol-4- yl}propan-2-ol | US10010539, 66 |
Type | Small organic molecule |
Emp. Form. | C20H26F2N4O3 |
Mol. Mass. | 408.4422 |
SMILES | C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1OC(F)F)n1nc(C)c(n1)C(C)(C)O |r| |
Structure |
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