Ki Summary

Reaction Details

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Target

Malignant T-cell-amplified sequence 1

Ligand

BDBM402876

Substrate/Competitor

n/a

Meas. Tech.

MTT assay

EC50

<20.0±n/a nM

Citation

Bannister, TD; Roush, WR; Choi, JY; Nair, R; Tsai, AS; Mishra, JK; Cleveland, JL Heterocyclic inhibitors of monocarboxylate transporter US Patent US10329303 Publication Date 6/25/2019

More Info.:

Get all data from this article, Assay Method

Malignant T-cell-amplified sequence 1

Name:

Malignant T-cell-amplified sequence 1

Synonyms:

MCT-1 | MCT1 | MCTS1 | MCTS1_HUMAN | Multiple copies T-cell malignancies

Type:

Enzyme Catalytic Domain

Mol. Mass.:

20563.62

Organism:

Homo sapiens (human)

Description:

n/a

Residue:

181

Sequence:

MFKKFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQIMPKKDPVKIVRCHEHIE
ILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPG
AKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTY
K

BDBM402876

n/a

Name

BDBM402876

Synonyms:

US10329303, Example 1

Type

Small organic molecule

Emp. Form.

C24H27FN4O3S

Mol. Mass.

470.56

SMILES

CC(C)Cn1c2sc(Cc3c(C)n[nH]c3C)c(-c3cccc(CO)c3F)c2c(=O)n(C)c1=O |(-4.16,-5.55,;-4.16,-4.01,;-5.5,-3.24,;-2.83,-3.24,;-2.83,-1.7,;-1.49,-.93,;-.03,-1.41,;.88,-.16,;2.42,-.16,;3.19,-1.49,;2.71,-2.96,;1.38,-3.73,;3.96,-3.86,;5.2,-2.96,;4.73,-1.49,;5.5,-.16,;-.03,1.09,;.37,2.57,;-.72,3.66,;-.32,5.15,;1.17,5.55,;2.25,4.46,;3.74,4.86,;4.83,3.77,;1.86,2.97,;2.95,1.88,;-1.49,.61,;-2.83,1.38,;-2.83,2.92,;-4.16,.61,;-5.5,1.38,;-4.16,-.93,;-5.5,-1.7,)|

Structure