Ki Summary

Reaction Details

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Target

Malignant T-cell-amplified sequence 1

Ligand

BDBM402974

Substrate/Competitor

n/a

Meas. Tech.

MTT assay

EC50

5500±n/a nM

Citation

Bannister, TD; Roush, WR; Choi, JY; Nair, R; Tsai, AS; Mishra, JK; Cleveland, JL Heterocyclic inhibitors of monocarboxylate transporter US Patent US10329303 Publication Date 6/25/2019

More Info.:

Get all data from this article, Assay Method

Malignant T-cell-amplified sequence 1

Name:

Malignant T-cell-amplified sequence 1

Synonyms:

MCT-1 | MCT1 | MCTS1 | MCTS1_HUMAN | Multiple copies T-cell malignancies

Type:

Enzyme Catalytic Domain

Mol. Mass.:

20563.62

Organism:

Homo sapiens (human)

Description:

n/a

Residue:

181

Sequence:

MFKKFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQIMPKKDPVKIVRCHEHIE
ILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPG
AKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTY
K

BDBM402974

n/a

Name

BDBM402974

Synonyms:

US10329303, Example 3

Type

Small organic molecule

Emp. Form.

C24H25F3N4O3S

Mol. Mass.

506.541

SMILES

CC(C)Cn1c2sc(Cc3c(C)n[nH]c3C)c(-c3c(F)cc(F)c(CO)c3F)c2c(=O)n(C)c1=O |(-4.16,-6.29,;-4.16,-4.75,;-5.5,-3.98,;-2.83,-3.98,;-2.83,-2.44,;-1.49,-1.67,;-.03,-2.15,;.88,-.9,;2.42,-.9,;3.19,-2.24,;2.71,-3.7,;1.38,-4.47,;3.96,-4.61,;5.2,-3.7,;4.73,-2.24,;5.5,-.9,;-.03,.34,;.37,1.83,;-.72,2.92,;-2.21,3.32,;-.32,4.41,;1.17,4.81,;1.56,6.29,;2.25,3.72,;3.74,4.12,;4.83,3.03,;1.86,2.23,;2.95,1.14,;-1.49,-.13,;-2.83,.64,;-2.83,2.18,;-4.16,-.13,;-5.5,.64,;-4.16,-1.67,;-5.5,-2.44,)|

Structure