Ki Summary

Reaction Details

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Target

Malignant T-cell-amplified sequence 1

Ligand

BDBM403184

Substrate/Competitor

n/a

Meas. Tech.

MTT assay

EC50

<20.0±n/a nM

Citation

Bannister, TD; Roush, WR; Choi, JY; Nair, R; Tsai, AS; Mishra, JK; Cleveland, JL Heterocyclic inhibitors of monocarboxylate transporter US Patent US10329303 Publication Date 6/25/2019

More Info.:

Get all data from this article, Assay Method

Malignant T-cell-amplified sequence 1

Name:

Malignant T-cell-amplified sequence 1

Synonyms:

MCT-1 | MCT1 | MCTS1 | MCTS1_HUMAN | Multiple copies T-cell malignancies

Type:

Enzyme Catalytic Domain

Mol. Mass.:

20563.62

Organism:

Homo sapiens (human)

Description:

n/a

Residue:

181

Sequence:

MFKKFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQIMPKKDPVKIVRCHEHIE
ILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPG
AKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTY
K

BDBM403184

n/a

Name

BDBM403184

Synonyms:

US10329303, Example 20

Type

Small organic molecule

Emp. Form.

C26H29FN4O3S

Mol. Mass.

496.597

SMILES

CC(C)Cn1c2sc(Cc3c(C)n[nH]c3C)c(-c3cccc(CO)c3F)c2c(=O)n(C2CC2)c1=O |(-3.39,-5.55,;-3.39,-4.01,;-4.73,-3.24,;-2.06,-3.24,;-2.06,-1.7,;-.72,-.93,;.74,-1.41,;1.65,-.16,;3.19,-.16,;3.96,-1.49,;3.48,-2.96,;2.15,-3.73,;4.73,-3.86,;5.97,-2.96,;5.5,-1.49,;6.27,-.16,;.74,1.09,;1.14,2.57,;.05,3.66,;.45,5.15,;1.94,5.55,;3.02,4.46,;4.51,4.86,;5.6,3.77,;2.63,2.97,;3.72,1.88,;-.72,.61,;-2.06,1.38,;-2.06,2.92,;-3.39,.61,;-4.73,1.38,;-6.27,1.38,;-5.5,2.71,;-3.39,-.93,;-4.73,-1.7,)|

Structure