| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/bile acid cotransporter |
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| Ligand | BDBM400027 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HBV DNA Quantification Assay |
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| EC50 | 11.1±n/a nM |
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| Citation |  Du, J; Kaplan, JA; Kirschberg, TA; Kobayashi, T; Lazerwith, SE; Lee, RA; Medley, JW; Mitchell, ML; Morganelli, PA; Pyun, H; Shevick, SL; Squires, NH; Watkins, WJ SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF US Patent US20230270719 Publication Date 8/31/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/bile acid cotransporter |
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| Name: | Sodium/bile acid cotransporter |
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| Synonyms: | Bile acid transporter | NTCP | NTCP_HUMAN | SLC10A1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 38131.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_838517 |
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| Residue: | 349 |
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| Sequence: | MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKG
LAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLSI
VMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKR
PQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVL
SALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLL
IAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA
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| BDBM400027 |
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| n/a |
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| Name | BDBM400027 |
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| Synonyms: | 7-(2-((1-(1H-1,2,3-Triazol-4-yl)cyclopropyl)amino)-2-oxoacetyl)-N-(3-chloro-4-fluorophenyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-5-carboxamide | US10328053, Compound 6 | US20230270719, Compound 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20ClFN6O3 |
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| Mol. Mass. | 470.884 |
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| SMILES | Cc1c(C(=O)C(=O)NC2(CC2)c2c[nH]nn2)c2CCCn2c1C(=O)Nc1ccc(F)c(Cl)c1 |
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| Structure | 
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