Ki Summary

Reaction Details

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Target

Focal adhesion kinase 1

Ligand

BDBM40960

Substrate/Competitor

n/a

Meas. Tech.

Dose-response biochemical assay for inhibitors of Focal Adhesion Kinase (FAK)

IC50

2179±n/a nM

Citation

PubChem, PC Dose-response biochemical assay for inhibitors of Focal Adhesion Kinase (FAK) PubChem Bioassay(2007)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Focal adhesion kinase 1

Name:

Focal adhesion kinase 1

Synonyms:

Type:

Tyrosine-protein kinase

Mol. Mass.:

119233.17

Organism:

Homo sapiens (Human)

Description:

Q05397

Residue:

1052

Sequence:

MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGD
ATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEW
KYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSY
WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESI
LKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQ
TIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFII
RPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRE
RIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDH
PHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK
RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFT
SASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWA
YDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGY
PSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQE
IAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLS
RGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNE
GVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLA
LRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQM
LTAAHALAVDAKNLLDVIDQARLKMLGQTRPH

BDBM40960

n/a

Name

BDBM40960

Synonyms:

2-[[[4-(4-chlorophenyl)-5-methyl-1H-pyrazol-3-yl]amino]methylene]-5,5-dimethyl-cyclohexane-1,3-quinone | 2-[[[4-(4-chlorophenyl)-5-methyl-1H-pyrazol-3-yl]amino]methylidene]-5,5-dimethyl-cyclohexane-1,3-dione | 2-[[[4-(4-chlorophenyl)-5-methyl-1H-pyrazol-3-yl]amino]methylidene]-5,5-dimethylcyclohexane-1,3-dione | MLS000084483 | SMR000048656 | cid_667314

Type

Small organic molecule

Emp. Form.

C19H20ClN3O2

Mol. Mass.

357.834

SMILES

Cc1n[nH]c(NC=C2C(=O)CC(C)(C)CC2=O)c1-c1ccc(Cl)cc1 |(8.76,5.94,;7.85,4.69,;6.31,4.69,;5.84,3.23,;7.08,2.32,;7.08,.78,;5.75,.01,;5.75,-1.53,;7.08,-2.3,;8.41,-1.53,;7.08,-3.84,;5.75,-4.61,;4.98,-5.94,;6.52,-5.94,;4.41,-3.84,;4.41,-2.3,;3.08,-1.53,;8.33,3.23,;9.79,2.75,;10.11,1.25,;11.58,.77,;12.72,1.8,;14.19,1.33,;12.4,3.31,;10.94,3.78,)|

Structure