| Reaction Details |
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 | Report a problem with these data |
| Target | Focal adhesion kinase 1 |
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| Ligand | BDBM41060 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose-response biochemical assay for inhibitors of Focal Adhesion Kinase (FAK) |
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| IC50 | 4027±n/a nM |
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| Citation |  PubChem, PC Dose-response biochemical assay for inhibitors of Focal Adhesion Kinase (FAK) PubChem Bioassay(2007)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Focal adhesion kinase 1 |
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| Name: | Focal adhesion kinase 1 |
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| Synonyms: | FADK 1 | FAK | FAK1 | FAK1_HUMAN | FLT4 | FRNK | Focal adhesion kinase (FAK) | Focal adhesion kinase (PTK2) | Focal adhesion kinase 1 (FAK) | Focal adhesion kinase 1/vascular endothelial growth factor receptor 3 | Focal adhesion kinase-related nonkinase | PPP1R71 | PTK2 | Protein phosphatase 1 regulatory subunit 71 | Protein-tyrosine kinase 2 | VHL/Focal adhesion kinase 1 | p125FAK | pp125FAK |
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| Type: | Tyrosine-protein kinase |
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| Mol. Mass.: | 119233.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q05397 |
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| Residue: | 1052 |
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| Sequence: | MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGD
ATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEW
KYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSY
WEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESI
LKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQ
TIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFII
RPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRE
RIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDH
PHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK
RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFT
SASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWA
YDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGY
PSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQE
IAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLS
RGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNE
GVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLA
LRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQM
LTAAHALAVDAKNLLDVIDQARLKMLGQTRPH
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| BDBM41060 |
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| n/a |
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| Name | BDBM41060 |
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| Synonyms: | 8-(2-thienyl)-8,10,11,12-tetrahydro-7H-benzo[a][4,7]phenanthrolin-9-one | 8-thiophen-2-yl-8,10,11,12-tetrahydro-7H-benzo[a][4,7]phenanthrolin-9-one | MLS000566463 | SMR000177770 | cid_619417 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16N2OS |
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| Mol. Mass. | 332.419 |
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| SMILES | O=C1CCCC2=C1C(Nc1ccc3ncccc3c21)c1cccs1 |c:5| |
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| Structure | 
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