| Reaction Details |
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 | Report a problem with these data |
| Target | DNA-directed RNA polymerase subunit beta |
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| Ligand | BDBM41217 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | RNA polymerase dose-response confirmation |
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| IC50 | >50000±0 nM |
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| Citation |  PubChem, PC RNA polymerase dose-response confirmation PubChem Bioassay(2008)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| DNA-directed RNA polymerase subunit beta |
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| Name: | DNA-directed RNA polymerase subunit beta |
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| Synonyms: | RNA polymerase beta subunit (EC 2.7.7.6) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 150595.80 |
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| Organism: | Escherichia coli |
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| Description: | A0A0E2LB94 |
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| Residue: | 1342 |
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| Sequence: | MVYSYTEKKRIRKDFGKRPQVLDVPYLLSIQLDSFQKFIEQDPEGQYGLEAAFRSVFPIQ
SYSGNSELQYVSYRLGEPVFDVQECQIRGVTYSAPLRVKLRLVIYEREAPEGTVKDIKEQ
EVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYR
GSWLDFEFDPKDNLFVRIDRRRKLPATIILRALNYTTEQILDLFFEKVIFEIRDNKLQME
LVPERLRGETASFDIEANGKVYVEKGRRITARHIRQLEKDDVKLIEVPVEYIAGKVVAKD
YIDESTGELICAANMELSLDLLAKLSQSGHKRIETLFTNDLDHGPYISETLRVDPTNDRL
SALVEIYRMMRPGEPPTREAAESLFENLFFSEDRYDLSAVGRMKFNRSLLREEIEGSGIL
SKDDIIDVMKKLIDIRNGKGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLS
LGDLDTLMPQDMINAKPISAAVKEFFGSSQLSQFMDQNNPLSEITHKRRISALGPGGLTR
ERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLSVYAQTNEYGFLETPYRKVTDGVVT
DEIHYLSAIEEGNYVIAQANSNLDEEGHFVEDLVTCRSKGESSLFSRDQVDYMDVSTQQV
VSVGASLIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMERAVAVDSGVTAVAKR
GGVVQYVDASRIVIKVNEDEMYPGEAGIDIYNLTKYTRSNQNTCINQMPCVSLGEPVERG
DVLADGPSTDLGELALGQNMRVAFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELACVS
RDTKLGPEEITADIPNVGEAALSKLDESGIVYIGAEVTGGDILVGKVTPKGETQLTPEEK
LLRAIFGEKASDVKDSSLRVPNGVSGTVIDVQVFTRDGVEKDKRALEIEEMQLKQAKKDL
SEELQILEAGLFSRIRAVLVAGGVEAEKLDKLPRDRWLELGLTDEEKQNQLEQLAEQYDE
LKHEFEKKLEAKRRKITQGDDLAPGVLKIVKVYLAVKRRIQPGDKMAGRHGNKGVISKIN
PIEDMPYDENGTPVDIVLNPLGVPSRMNIGQILETHLGMAAKGIGDKINAMLKQQQEVAK
LREFIQRAYDLGADVRQKVDLSTFSDEEVMRLAENLRKGMPIATPVFDGAKEAEIKELLK
LGDLPTSGQIRLYDGRTGEQFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLG
GKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGNHQMEPGMP
ESFNVLLKEIRSLGINIELEDE
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| BDBM41217 |
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| n/a |
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| Name | BDBM41217 |
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| Synonyms: | (2E)-2-[5-(2-chlorobenzyl)-4-keto-thiazolidin-2-ylidene]-3-keto-butyronitrile | (2E)-2-[5-[(2-chlorophenyl)methyl]-4-oxidanylidene-1,3-thiazolidin-2-ylidene]-3-oxidanylidene-butanenitrile | (2E)-2-[5-[(2-chlorophenyl)methyl]-4-oxo-1,3-thiazolidin-2-ylidene]-3-oxobutanenitrile | (2E)-2-[5-[(2-chlorophenyl)methyl]-4-oxo-2-thiazolidinylidene]-3-oxobutanenitrile | MLS000077521 | SMR000042324 | cid_661711 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11ClN2O2S |
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| Mol. Mass. | 306.767 |
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| SMILES | CC(=O)C(C#N)=C1NC(=O)C(Cc2ccccc2Cl)S1 |w:6.20| |
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| Structure | 
|
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