Reaction Details |
| Report a problem with these data |
Target | Lysosomal acid glucosylceramidase |
---|
Ligand | BDBM42274 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity |
---|
EC50 | >50000±n/a nM |
---|
Citation | PubChem, PC Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity PubChem Bioassay(2008)[AID] |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Lysosomal acid glucosylceramidase |
---|
Name: | Lysosomal acid glucosylceramidase |
Synonyms: | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase) |
Type: | Enzyme |
Mol. Mass.: | 59724.64 |
Organism: | Homo sapiens (Human) |
Description: | The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source. |
Residue: | 536 |
Sequence: | MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
|
|
|
BDBM42274 |
---|
n/a |
---|
Name | BDBM42274 |
Synonyms: | 2-(4-Methoxy-benzenesulfonylamino)-N-{[(tetrahydro-furan-2-ylmethyl)-carbamoyl]-methyl}-N-o-tolyl-acetamide | 2-[(4-methoxyphenyl)sulfonylamino]-N-(2-methylphenyl)-N-[2-oxidanylidene-2-(oxolan-2-ylmethylamino)ethyl]ethanamide | 2-[(4-methoxyphenyl)sulfonylamino]-N-(2-methylphenyl)-N-[2-oxo-2-(2-oxolanylmethylamino)ethyl]acetamide | 2-[(4-methoxyphenyl)sulfonylamino]-N-(2-methylphenyl)-N-[2-oxo-2-(oxolan-2-ylmethylamino)ethyl]acetamide | MLS000031838 | N-[2-keto-2-(tetrahydrofurfurylamino)ethyl]-2-[(4-methoxyphenyl)sulfonylamino]-N-(o-tolyl)acetamide | SMR000004757 | cid_648647 |
Type | Small organic molecule |
Emp. Form. | C23H29N3O6S |
Mol. Mass. | 475.558 |
SMILES | COc1ccc(cc1)S(=O)(=O)NCC(=O)N(CC(=O)NCC1CCCO1)c1ccccc1C |
Structure |
|