| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysosomal acid glucosylceramidase |
|---|
| Ligand | BDBM42283 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity |
|---|
| EC50 | >50000±n/a nM |
|---|
| Citation |  PubChem, PC Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity PubChem Bioassay(2008)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Lysosomal acid glucosylceramidase |
|---|
| Name: | Lysosomal acid glucosylceramidase |
|---|
| Synonyms: | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 59724.64 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source. |
|---|
| Residue: | 536 |
|---|
| Sequence: | MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
|
|
|
|---|
| BDBM42283 |
|---|
| n/a |
|---|
| Name | BDBM42283 |
|---|
| Synonyms: | 2-(4-Benzylamino-4H-[1,2,4]triazol-3-ylsulfanyl)-N-tert-butyl-acetamide | 2-[[4-(benzylamino)-1,2,4-triazol-3-yl]sulfanyl]-N-tert-butylacetamide | 2-[[4-(benzylamino)-1,2,4-triazol-3-yl]thio]-N-tert-butyl-acetamide | MLS000034273 | N-tert-butyl-2-[[4-[(phenylmethyl)amino]-1,2,4-triazol-3-yl]sulfanyl]ethanamide | N-tert-butyl-2-[[4-[(phenylmethyl)amino]-1,2,4-triazol-3-yl]thio]acetamide | SMR000014148 | cid_653197 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H21N5OS |
|---|
| Mol. Mass. | 319.425 |
|---|
| SMILES | CC(C)(C)NC(=O)CSc1nncn1NCc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
