Ki Summary

Reaction Details

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Target

Cell division control protein 42 homolog

Ligand

BDBM43222

Substrate/Competitor

n/a

Meas. Tech.

Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant

EC50

53810±n/a nM

Citation

PubChem, PC Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Cell division control protein 42 homolog

Name:

Cell division control protein 42 homolog

Synonyms:

CDC42 | CDC42_HUMAN | Cell division control protein 42 homolog | G25K GTP-binding protein | cell division cycle 42 (GTP binding protein, 25kDa)

Type:

PROTEIN

Mol. Mass.:

21258.36

Organism:

Homo sapiens (Human)

Description:

ChEMBL_652970

Residue:

191

Sequence:

MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG
QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR
DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPP
EPKKSRRCVLL

BDBM43222

n/a

Name

BDBM43222

Synonyms:

4-(2-bromanyl-4-methyl-phenyl)-3-pyrazin-2-yl-1H-1,2,4-triazole-5-thione | 4-(2-bromo-4-methyl-phenyl)-3-pyrazin-2-yl-1H-1,2,4-triazole-5-thione | 4-(2-bromo-4-methylphenyl)-3-(2-pyrazinyl)-1H-1,2,4-triazole-5-thione | 4-(2-bromo-4-methylphenyl)-3-pyrazin-2-yl-1H-1,2,4-triazole-5-thione | MLS000765201 | SMR000288606 | cid_931740

Type

Small organic molecule

Emp. Form.

C13H10BrN5S

Mol. Mass.

348.221

SMILES

Cc1ccc(c(Br)c1)-n1c(n[nH]c1=S)-c1cnccn1 |(5.79,-4.65,;5.79,-3.11,;7.12,-2.34,;7.12,-.8,;5.79,-.03,;4.46,-.8,;3.12,-.03,;4.46,-2.34,;5.79,1.51,;7.04,2.41,;6.56,3.88,;5.02,3.88,;4.54,2.41,;3.08,1.94,;8.5,1.94,;8.82,.43,;10.29,-.04,;11.43,.99,;11.11,2.49,;9.65,2.97,)|

Structure