| Reaction Details |
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 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 1-alpha/beta |
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| Ligand | BDBM43520 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose response cell-based assay to measure STAT1 inhibition |
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| IC50 | 9576±n/a nM |
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| Citation |  PubChem, PC Dose response cell-based assay to measure STAT1 inhibition PubChem Bioassay(2008)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Signal transducer and activator of transcription 1-alpha/beta |
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| Name: | Signal transducer and activator of transcription 1-alpha/beta |
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| Synonyms: | STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha |
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| Type: | Cytosolic Transcription Factor |
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| Mol. Mass.: | 87327.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA. |
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| Residue: | 750 |
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| Sequence: | MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL
LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ
RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR
EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK
RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV
LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV
KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN
EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE
PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT
RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL
LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP
ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT
DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
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| BDBM43520 |
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| n/a |
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| Name | BDBM43520 |
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| Synonyms: | 2-[(4-methyl-1-piperazinyl)methyl]-3-[[4-(2-naphthalenyl)-2-thiazolyl]methyl]-4-quinazolinone | 2-[(4-methylpiperazin-1-yl)methyl]-3-[(4-naphthalen-2-yl-1,3-thiazol-2-yl)methyl]quinazolin-4-one | 2-[(4-methylpiperazino)methyl]-3-[[4-(2-naphthyl)thiazol-2-yl]methyl]quinazolin-4-one | 2-[(4-methylpiperazino)methyl]-3-[[4-(2-naphthyl)thiazol-2-yl]methyl]quinazolin-4-one;hydrochloride | MLS000390650 | SMR000259689 | cid_5238107 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27N5OS |
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| Mol. Mass. | 481.612 |
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| SMILES | CN1CCN(Cc2nc3ccccc3c(=O)n2Cc2nc(cs2)-c2ccc3ccccc3c2)CC1 |
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| Structure | 
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