| Reaction Details |
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 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 1-alpha/beta |
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| Ligand | BDBM43538 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose response cell-based assay to measure STAT1 inhibition |
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| IC50 | 13500±n/a nM |
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| Citation |  PubChem, PC Dose response cell-based assay to measure STAT1 inhibition PubChem Bioassay(2008)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Signal transducer and activator of transcription 1-alpha/beta |
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| Name: | Signal transducer and activator of transcription 1-alpha/beta |
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| Synonyms: | STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha |
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| Type: | Cytosolic Transcription Factor |
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| Mol. Mass.: | 87327.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA. |
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| Residue: | 750 |
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| Sequence: | MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL
LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ
RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR
EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK
RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV
LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV
KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN
EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE
PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT
RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL
LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP
ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT
DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
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| BDBM43538 |
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| n/a |
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| Name | BDBM43538 |
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| Synonyms: | 1-methyl-2-[4-(4-nitrophenyl)piperazin-1-yl]carbonyl-5H-pyrrolo[3,2-c]quinolin-4-one | 1-methyl-2-[4-(4-nitrophenyl)piperazine-1-carbonyl]-5H-pyrrolo[3,2-c]quinolin-4-one | 1-methyl-2-[[4-(4-nitrophenyl)-1-piperazinyl]-oxomethyl]-5H-pyrrolo[3,2-c]quinolin-4-one | 1-methyl-2-{[4-(4-nitrophenyl)piperazin-1-yl]carbonyl}-1,5-dihydro-4H-pyrrolo[3,2-c]quinolin-4-one | MLS000674638 | SMR000314079 | cid_16195389 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21N5O4 |
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| Mol. Mass. | 431.4439 |
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| SMILES | Cn1c(cc2c1c1ccccc1[nH]c2=O)C(=O)N1CCN(CC1)c1ccc(cc1)[N+]([O-])=O |
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| Structure | 
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