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TargetSignal transducer and activator of transcription 1-alpha/beta
LigandBDBM43548
Substrate/Competitorn/a
Meas. Tech.Dose response counterscreen assay for STAT3 activators: cell-based high throughput assay to measure STAT1 activation
EC50>55700±n/a nM
Citation PubChem, PC Dose response counterscreen assay for STAT3 activators: cell-based high throughput assay to measure STAT1 activation PubChem Bioassay(2008)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Signal transducer and activator of transcription 1-alpha/beta
Name:Signal transducer and activator of transcription 1-alpha/beta
Synonyms:STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha
Type:Cytosolic Transcription Factor
Mol. Mass.:87327.69
Organism:Homo sapiens (Human)
Description:Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA.
Residue:750
Sequence:
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL
LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ
RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR
EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK
RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV
LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV
KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN
EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE
PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT
RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL
LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP
ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT
DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
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  Blast E-value cutoff:
BDBM43548
n/a
NameBDBM43548
Synonyms:5-(1H-Indol-3-ylmethyl)-[1,3,4]thiadiazol-2-ylamine | 5-(1H-indol-3-ylmethyl)-1,3,4-thiadiazol-2-amine | MLS000069089 | SMR000010870 | [5-(1H-indol-3-ylmethyl)-1,3,4-thiadiazol-2-yl]amine | cid_654218
TypeSmall organic molecule
Emp. Form.C11H10N4S
Mol. Mass.230.289
SMILESNc1nnc(Cc2c[nH]c3ccccc23)s1
Structure
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