| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 1-alpha/beta |
|---|
| Ligand | BDBM43564 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Dose response counterscreen assay for STAT3 activators: cell-based high throughput assay to measure STAT1 activation |
|---|
| EC50 | >55700±n/a nM |
|---|
| Citation |  PubChem, PC Dose response counterscreen assay for STAT3 activators: cell-based high throughput assay to measure STAT1 activation PubChem Bioassay(2008)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Signal transducer and activator of transcription 1-alpha/beta |
|---|
| Name: | Signal transducer and activator of transcription 1-alpha/beta |
|---|
| Synonyms: | STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha |
|---|
| Type: | Cytosolic Transcription Factor |
|---|
| Mol. Mass.: | 87327.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA. |
|---|
| Residue: | 750 |
|---|
| Sequence: | MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL
LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ
RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR
EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK
RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV
LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV
KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN
EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE
PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT
RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL
LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP
ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT
DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
|
|
|
|---|
| BDBM43564 |
|---|
| n/a |
|---|
| Name | BDBM43564 |
|---|
| Synonyms: | 2-[5-amino-1-(4-chlorophenyl)-3-methyl-4-pyrazolyl]-1,1,1-trifluoro-3-[(1-methyl-2-imidazolyl)thio]-2-propanol | 2-[5-amino-1-(4-chlorophenyl)-3-methyl-pyrazol-4-yl]-1,1,1-trifluoro-3-[(1-methylimidazol-2-yl)thio]propan-2-ol | 2-[5-amino-1-(4-chlorophenyl)-3-methylpyrazol-4-yl]-1,1,1-trifluoro-3-(1-methylimidazol-2-yl)sulfanylpropan-2-ol | 2-[5-azanyl-1-(4-chlorophenyl)-3-methyl-pyrazol-4-yl]-1,1,1-tris(fluoranyl)-3-(1-methylimidazol-2-yl)sulfanyl-propan-2-ol | MLS000057835 | SMR000063198 | cid_2999297 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H17ClF3N5OS |
|---|
| Mol. Mass. | 431.863 |
|---|
| SMILES | Cc1nn(c(N)c1C(O)(CSc1nccn1C)C(F)(F)F)-c1ccc(Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
